Breakdown Value insidersPercentHeld 0.10786 institutionsPercentHeld 0.45993 institutionsFloatPercentHeld 0.51554 institutionsCount 84.00000

Date Reported                                        Holder  pctHeld   Shares     Value

0 2023-06-30 Avoro Capital Advisors LLC 0.1162 2849402 19489909 1 2023-06-30 Acuta Capital Partners LLC 0.0754 1849402 12649909 2 2023-06-30 Alerce Investment Management, L.P. 0.0665 1630830 11154877 3 2023-06-30 Blackrock Inc. 0.0415 1017124 6957128 4 2023-06-30 Baker Brothers Advisors, LLC 0.0404 989928 6771107 5 2023-06-30 Vanguard Group Inc 0.0311 761904 5211423 6 2023-06-30 Janus Henderson Group PLC 0.0217 531632 3636362 7 2023-06-30 Decheng Capital Management III (Cayman), LLC 0.0215 526329 3600090 8 2023-06-30 Vivo Capital, LLC 0.0208 509572 3485472 9 2023-06-30 Soleus Capital Management, L.P. 0.0136 333227 2279272

   Shares     Value URL                                                                    Text                         Insider                                                               Position Transaction Start Date Ownership

0 40000 57354 Sale at price 1.34 - 1.50 per share. DESAI NEIL Officer and Director 2024-08-05 I 1 40000 57217 Sale at price 1.34 - 1.45 per share. DESAI NEIL Officer and Director 2024-07-02 I 2 40000 71511 Sale at price 1.77 - 1.81 per share. DESAI NEIL Officer and Director 2024-06-04 I 3 40000 77184 Sale at price 1.93 per share. DESAI NEIL Officer and Director 2024-05-01 I 4 40000 90614 Sale at price 2.23 - 2.31 per share. DESAI NEIL Officer and Director 2024-04-02 I 5 42000 84641 Sale at price 1.97 - 2.10 per share. DESAI NEIL Officer and Director 2024-03-04 I 6 42000 73269 Sale at price 1.74 per share. DESAI NEIL Officer and Director 2024-02-01 I 7 42000 86549 Sale at price 2.06 per share. DESAI NEIL Officer and Director 2024-01-02 I 8 7037 33914 Sale at price 4.82 per share. DESAI NEIL Officer and Director 2023-12-06 I 9 34963 177808 Sale at price 5.02 - 5.15 per share. DESAI NEIL Officer and Director 2023-12-05 I 10 42000 185750 Sale at price 4.32 - 4.46 per share. DESAI NEIL Officer and Director 2023-11-02 I 11 42000 179001 Sale at price 4.10 - 4.37 per share. DESAI NEIL Officer and Director 2023-10-03 I 12 42000 238826 Sale at price 5.29 - 5.97 per share. DESAI NEIL Officer and Director 2023-09-06 I 13 42000 218774 Sale at price 5.20 - 5.22 per share. DESAI NEIL Officer and Director 2023-08-02 I 14 42000 271592 Sale at price 6.27 - 6.64 per share. DESAI NEIL Officer and Director 2023-07-06 I 15 7260 59453 Sale at price 8.19 per share. DESAI NEIL Officer, Director and Beneficial Owner 2023-06-06 I 16 34740 279307 Sale at price 7.92 - 8.11 per share. DESAI NEIL Officer, Director and Beneficial Owner 2023-06-05 I 17 2305 17445 Sale at price 7.57 per share. DESAI NEIL Officer, Director and Beneficial Owner 2023-05-04 I 18 39695 306192 Sale at price 7.48 - 7.80 per share. DESAI NEIL Officer, Director and Beneficial Owner 2023-05-03 I 19 12212 86616 Sale at price 7.09 per share. DESAI NEIL Officer, Director and Beneficial Owner 2023-04-06 I 20 29788 218412 Sale at price 7.24 - 7.45 per share. DESAI NEIL Officer, Director and Beneficial Owner 2023-04-05 I 21 320000 4000000 Stock Award(Grant) at price 12.50 per share. DALAL ANUPAM M.D. Director 2022-09-26 I 22 240000 3000000 Stock Award(Grant) at price 12.50 per share. CASTELEIN CALEY M. Director 2022-09-26 I 23 20000 250000 Stock Award(Grant) at price 12.50 per share. DELANEY BRENDAN P Chief Operating Officer 2022-09-26 D 24 20000 250000 Stock Award(Grant) at price 12.50 per share. GIACOBELLO SCOTT M Chief Financial Officer 2022-09-26 D 25 1260000 15750000 Stock Award(Grant) at price 12.50 per share. AGHAZADEH BEHZAD PH.D. Director and Beneficial Owner of more than 10% of a Class of Security 2022-09-22 I 26 3550 71234 Sale at price 20.07 per share. DESAI NEIL Chief Executive Officer 2022-03-18 I 27 1529402 3364684 Purchase at price 2.20 per share. DALAL ANUPAM M.D. Director 2021-08-26 I 28 259998 571996 Purchase at price 2.20 per share. CASTELEIN CALEY M. Director 2021-08-26 I 29 1911752 4205854 Stock Award(Grant) at price 2.20 per share. AGHAZADEH BEHZAD PH.D. Director and Beneficial Owner of more than 10% of a Class of Security 2021-08-26 I 30 12334 18748 Stock Award(Grant) at price 1.52 per share. PRELACK STEVEN Director 2021-06-30 D 31 8140 12373 Stock Award(Grant) at price 1.52 per share. COHEN CHERYL L Director 2021-06-30 D 32 7400 11248 Stock Award(Grant) at price 1.52 per share. DALAL ANUPAM M.D. Director 2021-06-30 D 33 7811 11873 Stock Award(Grant) at price 1.52 per share. CASTELEIN CALEY M. Director 2021-06-30 D 34 6331 9623 Stock Award(Grant) at price 1.52 per share. DUGEL PRAVIN U Director 2021-06-30 D 35 12151 18749 Stock Award(Grant) at price 1.54 per share. PRELACK STEVEN Director 2021-03-31 D 36 8020 12375 Stock Award(Grant) at price 1.54 per share. COHEN CHERYL L Director 2021-03-31 D 37 7290 11248 Stock Award(Grant) at price 1.54 per share. DALAL ANUPAM M.D. Director 2021-03-31 D 38 7696 11875 Stock Award(Grant) at price 1.54 per share. CASTELEIN CALEY M. Director 2021-03-31 D 39 6237 9624 Stock Award(Grant) at price 1.54 per share. DUGEL PRAVIN U Director 2021-03-31 D 40 21400 41944 Sale at price 1.96 per share. ORBIMED ADVISORS, L.L.C. Beneficial Owner of more than 10% of a Class of Security 2020-12-08 I 41 21400 20544 Conversion of Exercise of derivative security at price 0.96 per share. ORBIMED ADVISORS, L.L.C. Beneficial Owner of more than 10% of a Class of Security 2020-12-08 I 42 5000 4074 Purchase at price 0.81 per share. GARDNER JOSEPH H President 2019-07-10 D 43 5000 4485 Purchase at price 0.90 per share. GARDNER JOSEPH H President 2019-07-03 D 44 701800 722854 Sale at price 1.03 per share. NOVARTIS BIOVENTURES, LTD. Beneficial Owner of more than 10% of a Class of Security 2019-04-26 I 45 51057 52163 Sale at price 0.97 - 1.03 per share. NOVARTIS BIOVENTURES, LTD. Beneficial Owner of more than 10% of a Class of Security 2019-04-24 I 46 117140 122683 Sale at price 0.99 - 1.08 per share. NOVARTIS BIOVENTURES, LTD. Beneficial Owner of more than 10% of a Class of Security 2019-04-15 I 47 200746 214247 Sale at price 1.01 - 1.09 per share. NOVARTIS BIOVENTURES, LTD. Beneficial Owner of more than 10% of a Class of Security 2019-04-10 I 48 130594 129245 Sale at price 0.96 - 1.02 per share. NOVARTIS BIOVENTURES, LTD. Beneficial Owner of more than 10% of a Class of Security 2019-04-05 I 49 231763 218686 Sale at price 0.91 - 0.97 per share. NOVARTIS BIOVENTURES, LTD. Beneficial Owner of more than 10% of a Class of Security 2019-04-02 I 50 317346 313286 Sale at price 0.94 - 1.01 per share. NOVARTIS BIOVENTURES, LTD. Beneficial Owner of more than 10% of a Class of Security 2019-03-28 I 51 63818 150290 Purchase at price 2.20 - 2.45 per share. SATTER MANAGEMENT CO., L.P. Director and Beneficial Owner of more than 10% of a Class of Security 2019-01-10 I 52 60000 127462 Purchase at price 2.08 - 2.18 per share. SATTER MANAGEMENT CO., L.P. Director and Beneficial Owner of more than 10% of a Class of Security 2019-01-07 I 53 60000 108110 Purchase at price 1.72 - 1.94 per share. SATTER MANAGEMENT CO., L.P. Director and Beneficial Owner of more than 10% of a Class of Security 2019-01-02 I 54 60000 104134 Purchase at price 1.67 - 1.84 per share. SATTER MANAGEMENT CO., L.P. Director and Beneficial Owner of more than 10% of a Class of Security 2018-12-27 I 55 60000 115224 Purchase at price 1.85 - 1.99 per share. SATTER MANAGEMENT CO., L.P. Director and Beneficial Owner of more than 10% of a Class of Security 2018-12-20 I 56 60000 121340 Purchase at price 2.00 - 2.05 per share. SATTER MANAGEMENT CO., L.P. Director and Beneficial Owner of more than 10% of a Class of Security 2018-12-14 I 57 150000 0 Stock Gift at price 0.00 per share. GARDNER JOSEPH H President 2018-12-12 D 58 60000 127242 Purchase at price 2.09 - 2.14 per share. SATTER MANAGEMENT CO., L.P. Director and Beneficial Owner of more than 10% of a Class of Security 2018-12-11 I 59 60000 125352 Purchase at price 1.99 - 2.18 per share. SATTER MANAGEMENT CO., L.P. Director and Beneficial Owner of more than 10% of a Class of Security 2018-12-06 I 60 60000 118524 Purchase at price 1.94 - 2.01 per share. SATTER MANAGEMENT CO., L.P. Director and Beneficial Owner of more than 10% of a Class of Security 2018-11-30 I 61 31967 64136 Purchase at price 1.95 - 2.01 per share. HOFFMAN STEPHEN J. M.D., PH.D. Chief Executive Officer 2018-11-12 D 62 5300 20670 Sale at price 3.90 per share. NOVARTIS BIOVENTURES, LTD. Beneficial Owner of more than 10% of a Class of Security 2018-08-20 I 63 1818182 7000001 Purchase at price 3.85 per share. SATTER MANAGEMENT CO., L.P. Director and Beneficial Owner of more than 10% of a Class of Security 2018-06-28 I 64 777500 2993375 Purchase at price 3.85 per share. KHUONG CHAU QUANG Director and Beneficial Owner of more than 10% of a Class of Security 2018-06-28 I 65 777500 2993375 Purchase at price 3.85 per share. ORBIMED ADVISORS, L.L.C. Director and Beneficial Owner of more than 10% of a Class of Security 2018-06-28 I 66 5000 24390 Purchase at price 4.85 - 5.00 per share. SATTER MANAGEMENT CO., L.P. Director and Beneficial Owner of more than 10% of a Class of Security 2018-03-23 I 67 13000 64585 Purchase at price 4.96 - 4.97 per share. SATTER MANAGEMENT CO., L.P. Director and Beneficial Owner of more than 10% of a Class of Security 2018-03-20 I